The loan move of Gabor Kiraly to Aston Villa, coupled with Iain Turner's groin injury, leaves boss Peter Taylor with only Scott Flinders and Julian Speroni to choose from between the sticks.
Flinders has conceded 10 in his three league appearances this season, while Speroni has not yet featured due to injury.
The Eagles defence is also weakened, with the continued absence of Leon Cort, Danny Granville and Danny Butterfield.
But Palace have their own problems up front, with striker Dougie Freedman still out injured.
Top scorer Steve Howard, who has notched nine times for the Rams this season, is out through suspension. However,
Probable Palace XI
Soares Fletcher Hughes McAnuff