Winger Mujangi has been signed on loan from RSC Charleroi for the remainder of the season with an option for the deal to become permanent in the summer.
Wolves boss Mick McCarthy will be forced to make one defensive change with full-back Richard Stearman suspended after his sending-off against Wigan last weekend.
McCarthy confirmed out-of-form striker Sylvan Ebanks-Blake will retain his place in the starting line-up against Neil Warnock's side.
Crystal Palace will be without Lee Hills.
The young left-back is cup-tied having played in the competition earlier this season while on loan at Oldham.
Danny Butterfield, who recovered from a hamstring injury to make a substitute appearance at Plymouth last week, could come into the back four.
Palace expect in-demand teenage striker Victor Moses to be in the squad.
The England Under-19 star is poised to be sold during the transfer window but, barring any dramatic developments ahead of the weekend, he will travel to Molineux.
Nick Carle is unlikely to be involved as he weighs up a move to China while Sean Scannell (hamstring), Paddy McCarthy (shoulder) and Darryl Flahavan (jaw) are still missing.
Wolves (from): Hahnemann, Zubar, Craddock, Mancienne, Ward, Jarvis, Milijas, Foley, Henry, Ebanks-Blake, Doyle, Hennessey, Elokobi, Surman, Jones, Berra, Vokes, Iwelumo, Mujangi.