The big centre-half suffered a groin tear in training last week.
But fellow Palace old-boys Ben Watson - who made his Rangers debut against Peterborough on Saturday - Mikele Leigertwood, Wayne Routledge and Gary Borrowdale should all line up against their former employers.
Striker Heidar Helguson missed the 1-1 draw at the weekend with a knee problem and will be checked over while Kaspars Gorkss could return in defence.
Skipper Martin Rowlands will push for a start after returning as a substitute against Posh following an ankle injury.
Lee Cook (knee), Gareth Ainsworth (hamstring) and Angelo Balanta (groin) are still out.
Paddy McCarthy returns to the Crystal Palace squad for the short trip across London.
The centre-half missed out against Scunthorpe on Saturday due to a one-match ban and can expect to go straight back into the starting line-up following the humiliating 4-0 defeat.
Claude Davis is still waiting to make his second debut since joining permanently from Derby, although he may need to build up his match fitness in the reserves first.
Striker Freddie Sears was limping at the end of Saturday's game and will be checked over.
Angry boss Neil Warnock has promised changes following the weekend debacle so Sean Scannell, Nathanial Clyne, Nick Carle and Ryan Smith could all feature.
Stern John (elbow) and Calvin Andrew (knee) are still missing.