Vaughan is rated 50-50 with an ankle injury in what will be the final match of his loan spell from Everton.
Fellow strikers Steffen Iversen and Pablo Counago are in line to return to the squad.
Iversen missed last week's draw at Hull with an ankle knock and Counago was absent through illness.
Manager Dougie Freedman is also boosted by the return of midfielder Neil Danns and winger Sean Scannell from suspension.
Left-back Lee Hills (knee) and midfielder Alex Marrow (ankle) remain long-term absentees for Palace, who secured their Championship survival with the point they picked up at the KC Stadium.